On the integrity of functional brain networks in schizophrenia, Parkinson's disease, and advanced age: Evidence from connectivity-based single-subject classification
| Autor: | Anne. Latz, Felix Hoffstaedter, Robert Langner, Tobias Kalenscher, Rachel Pläschke, Martin Südmeyer, Veronika I. Müller, Julian Caspers, Oliver Gruber, Simon B. Eickhoff, Christian Mathys, Svenja Caspers, Anna Plachti, Edna C. Cieslik, Susanne Moebus, Mareike. Goosses, Claudia R. Eickhoff, Christiane Jockwitz, Kathrin Reetz, Julia Heller, Deepthi P. Varikuti, Christian Grefkes |
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| Rok vydání: | 2017 |
| Předmět: |
Parkinson's disease
media_common.quotation_subject Empathy Disease 050105 experimental psychology Developmental psychology 03 medical and health sciences 0302 clinical medicine medicine Semantic memory 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging media_common Radiological and Ultrasound Technology Resting state fMRI Functional connectivity 05 social sciences Cognition medicine.disease Neurology Schizophrenia Neurology (clinical) Anatomy Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping. 38:5845-5858 |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.23763 |
| Popis: | Previous whole-brain functional connectivity studies achieved successful classifications of patients and healthy controls but only offered limited specificity as to affected brain systems. Here, we examined whether the connectivity patterns of functional systems affected in schizophrenia (SCZ), Parkinson's disease (PD), or normal aging equally translate into high classification accuracies for these conditions. We compared classification performance between pre-defined networks for each group and, for any given network, between groups. Separate support vector machine classifications of 86 SCZ patients, 80 PD patients, and 95 older adults relative to their matched healthy/young controls, respectively, were performed on functional connectivity in 12 task-based, meta-analytically defined networks using 25 replications of a nested 10-fold cross-validation scheme. Classification performance of the various networks clearly differed between conditions, as those networks that best classified one disease were usually non-informative for the other. For SCZ, but not PD, emotion-processing, empathy, and cognitive action control networks distinguished patients most accurately from controls. For PD, but not SCZ, networks subserving autobiographical or semantic memory, motor execution, and theory-of-mind cognition yielded the best classifications. In contrast, young-old classification was excellent based on all networks and outperformed both clinical classifications. Our pattern-classification approach captured associations between clinical and developmental conditions and functional network integrity with a higher level of specificity than did previous whole-brain analyses. Taken together, our results support resting-state connectivity as a marker of functional dysregulation in specific networks known to be affected by SCZ and PD, while suggesting that aging affects network integrity in a more global way. Hum Brain Mapp 38:5845-5858, 2017. © 2017 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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