Chronic Myeloid Leukemia: Comparison of Survival between Pregnant and Non-Pregnant Women
| Autor: | Vanderson Rocha, Thales Augusto Zamberlan Pereira, Fernanda Maria Santos, Lucas Bassolli de Oliveira Alves, Giovanna Iantevi Ghelfond, Israel Bendit, Fernanda S Seguro, Felipe Vieira Rodrigues Maciel, Eduardo Magalhães Rego, Andre Abdo |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Blood. 136:37-38 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | The management of chronic myeloid leukemia (CML) during pregnancy is a subject of continuous debate and there are few reports on CML outcomes in these women. The aim of the study is to compare progression-free survival (PFS) and overall survival (OS) between women who became pregnant after the diagnosis of CML and those who did not, as well as describing the treatments performed during pregnancy and maternal-fetal outcomes.Methods:Retrospective study, including women under 45 years of age and diagnosis of CML between 1991 and 2018, from the database of the Clinical's Hospital of the University of Medical School of São Paulo and the Cancer Institute of the State of São Paulo-Brazil.Results:100 cases were reviewed and 98 were included for analysis. The PFS and OS of groups A (63 non-pregnant women) and B (35 pregnant women, totaling 46 pregnancies) did not show statistical difference in a median of 11 years of follow-up (p=0.15). In the multivariate analysis, only poor adherence to treatment was identified as an independent risk factor for PFS and OS (HR: 9.7, 95% CI: 1.9-47.7). Comparing women with unplanned pregnancies (group B-UP, n= 21) with group A and considering adherence, PFS was worse in group B-UP without adherence (p Disclosures No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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