Starter units of the biosynthesis of blepharismins: self-defense pigments of Blepharisma japonicum

Autor:	Sohei Tominaga, Yoshinosuke Usuki, Koichi Yoshioka, Hideo Iio, Yoshiyuki Uruma
Rok vydání:	2008
Předmět:	biology Blepharisma japonicum Organic Chemistry Sodium butyrate biology.organism_classification Biochemistry Isovaleryl-CoA chemistry.chemical_compound Polyketide Pigment chemistry Biosynthesis visual_art Drug Discovery visual_art.visual_art_medium Leucine Heterotrich
Zdroj:	Tetrahedron. 64:4103-4107
ISSN:	0040-4020
DOI:	10.1016/j.tet.2008.02.004
Popis:	The heterotrich ciliate Blepharisma japonicum produces red pigment blepharismins, which function as self-defense toxin against predators and as a photoreceptor for step-up photonegativity. The dibenzoperylenequinone moiety of blepharismins was shown to be biosynthesized via the polyketide pathway. In this paper, the starter units of the biosynthetic pathway of blepharismins were determined to be isovaleryl-CoA and butyryl-CoA by HPLC, LC/ESI-MS, and 1 H and 2 H NMR analyses of the pigments obtained from feeding experiment of l -leucine or sodium butyrate in excess and deuterium-labeled l -leucine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b94cac779d149266c40e312ac42ce20e https://doi.org/10.1016/j.tet.2008.02.004 Zobrazit plný text záznamu Full Text from ScienceDirect