| Autor: |
Hurley, C., AIDS Clinical Trials Group A5342 Protocol Team, Ritz, J., Storey, S., Gottesman, J., Sbrolla, A., Macatangay, B.J.C., Kessels, L., Arduino, R.C., Acosta, Ed., Perelson, A., Ray, G., Eron, J.J., Ledgerwood, J., Baer, J., Zheng, L., Lambert, N., Kudumu, M., Koup, R.A., Campbell, D., Tipton, M., Bunce, C.A., Epperson, K., Villamil, A.E., Sise, T., Casazza, J., Jennings, C., Dunaway, S., Tressler, R., Nair, A., Leonard, M., Cyktor, J.C., Bailer, R.T., Hite, M., Howard, J., Muttera, L., Clark, J., Weinman, R., Mellors, J.W., Durand, C.M., Koletar, S.L., Flynn, T., Benns, A., Keefer, M.C., Berzins, B., Currin, D., Riddler, S.A., Benson, C., Kittelson, P., Spitz, T., Wiggins, I., Onesi, S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| DOI: |
10.17615/p8th-zw41 |
| Popis: |
Background. Broadly neutralizing monoclonal antibodies (bnMAbs) may promote clearance of HIV-1-expressing cells through antibody-dependent cell-mediated cytotoxicity. We evaluated the effect of the CD4-binding site bnMAb, VRC01, on measures of HIV-1 persistence in chronically infected individuals. Methods. A5342 was a phase 1, randomized, double-blind, placebo-controlled, parallel-arm study. Participants on effective antiretroviral therapy (ART) were randomized to receive 2 infusions of VRC01 (40 mg/kg) at entry and week 3, and 2 infusions of placebo (saline) at weeks 6 and 9; or 2 infusions of placebo at entry and week 3, and 2 infusions of VRC01 at weeks 6 and 9. Results. Infusion of VRC01 was safe and well tolerated. The median fold-change in the cell-associated HIV-1 RNA/DNA ratio from baseline to week 6 was 1.12 and 0.83 for the VRC01 and placebo arms, respectively, with no significant difference between arms (P = .16). There were no significant differences in the proportions with residual plasma viremia ≥1 copies/mL or in phorbol 12-myristate 13-acetate/ionomycin-induced virus production from CD4+ T cells between arms (both P > .05). Conclusions. In individuals with chronic HIV-1 infection on ART, VRC01 infusions were safe and well tolerated but did not affect plasma viremia, cellular HIV-1 RNA/DNA levels, or stimulated virus production from CD4+ T cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
