Transiente Myeloproliferation und akute myeloische Leukämie bei Säuglingen mit Morbus Down
| Autor: | Günther Schellong, Jörg Ritter, R. Dickerhoff, C. Eschenbach, S. Burdach, Josef Vormoor, H. G. Scheel-Walter, U. Creutzig, J Kühl |
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| Rok vydání: | 1990 |
| Předmět: |
Down syndrome
Pathology medicine.medical_specialty Pediatrics Myeloid business.industry Poorly differentiated Diagnostico diferencial medicine.disease Acute myelogenous leukaemia Myeloproliferative Disorders medicine.anatomical_structure Pediatrics Perinatology and Child Health Medicine Clinical significance Differential diagnosis business |
| Zdroj: | Klinische Pädiatrie. 202:253-257 |
| ISSN: | 1439-3824 0300-8630 |
| Popis: | Transient neonatal myeloproliferative disorders (TMD's) indistinguishable from acute leukaemia by clinical and morphological criteria have been described in neonates with Down's syndrome. To analyse its clinical significance, 10 infants under 1 year of age presenting with Down's syndrome and the morphological picture of acute myelogenous leukaemia were reviewed. 3 of these children had true AML leading to death after 2, 8 and 11 months. In the other 7 children the diagnosis TMD was suggested as spontaneous or in one case interferon-induced remission occurred within 4 to 25 weeks after diagnosis. The interferon-treated patient died of SIDS at the age of 11 months. Another one of the TMD children developed fatal erythroleukaemia at the age of 2 years. Regarding initial clinical and haematological parameters, TMD was indistinguishable from true congenital leukaemie. In all patients classification according to the FAB criteria was difficult, as mainly undifferentiated or poorly differentiated myeloid blasts were seen, sometimes with erythro- or megakaryocytic features. Because of the difficulties in the differential diagnosis of TMD and true AML it is recommended to delay specific cytostatic therapy in neonates with Down's syndrome, until definite progression of the leukaemic process is observed or cytogenetic analyses suggesting true AML are available. |
| Databáze: | OpenAIRE |
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