Determination and correlation of solubility and solution thermodynamics of ethenzamide in different pure solvents
| Autor: | Leping Dang, Yao Tong, Entao Yang, Bochen Pan, Hongyuan Wei, Jun Jiang, Zhanzhong Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Activity coefficient
General Chemical Engineering Enthalpy Ethenzamide Ethyl acetate General Physics and Astronomy Thermodynamics 02 engineering and technology 010402 general chemistry 01 natural sciences 0104 chemical sciences Gibbs free energy chemistry.chemical_compound symbols.namesake 020401 chemical engineering chemistry medicine symbols Gravimetric analysis Physics::Chemical Physics 0204 chemical engineering Physical and Theoretical Chemistry Solubility Dissolution medicine.drug |
| Zdroj: | Fluid Phase Equilibria. 427:549-556 |
| ISSN: | 0378-3812 |
| DOI: | 10.1016/j.fluid.2016.08.019 |
| Popis: | The solubility of ethenzamide in methanol, ethanol, 1-propanol, isobutanol, ethyl acetate and acetonitrile was determined via the gravimetric method in the temperature range from 288.15 K to 323.15 K at atmospheric pressure. Five thermodynamic models were employed to correlate the experimental solubility data. The correlated results were analyzed and compared with the experimental results. It was found that all the thermodynamic models give satisfactory correlation results, in which the modified Apelblat model shows the best fitting result. In addition, the molecular modeling studies were carried out to give the explanation for the sequence of solubility in various solvents. The dissolution enthalpy and entropy of ethenzamide were obtained by using the Van't Hoff equation. Furthermore, the mixing thermodynamic properties of ethenzamide, including the mixing Gibbs energy, the mixing enthalpy and entropy, as well as the infinite-dilution activity coefficient and the infinitesimal concentration reduced excess enthalpy, were also obtained by using the Wilson model and the experimental solubility values. |
| Databáze: | OpenAIRE |
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