Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort
| Autor: | Kaitlin J Mayne, Jennifer S Lees, Elaine Rutherford, Peter C Thomson, Jamie P Traynor, Vishal Dey, Ninian N Lang, Patrick B Mark |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Clinical Kidney Journal. 16:512-520 |
| ISSN: | 2048-8513 2048-8505 |
| Popis: | BackgroundLymphocyte ratios reflect inflammation and have been associated with adverse outcomes in a range of diseases. We sought to determine any association between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) and mortality in a haemodialysis cohort, including a coronavirus disease 2019 (COVID-19) infection subpopulation.MethodsA retrospective analysis was performed of adults commencing hospital haemodialysis in the West of Scotland during 2010–21. NLR and PLR were calculated from routine samples around haemodialysis initiation. Kaplan–Meier and Cox proportional hazards analyses were used to assess mortality associations.ResultsIn 1720 haemodialysis patients over a median of 21.9 (interquartile range 9.1–42.9) months, there were 840 all-cause deaths. NLR but not PLR was associated with all-cause mortality after multivariable adjustment [adjusted hazard ratio (aHR) for in participants with baseline NLR in quartile 4 (NLR ≥8.23) versus quartile 1 (NLR ConclusionsNLR is strongly associated with mortality in haemodialysis patients while the association between PLR and adverse outcomes is weaker. NLR is an inexpensive, readily available biomarker with potential utility in risk stratification of haemodialysis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|