A method to measure the extent of myocardial ischemia and steal with SPECT myocardial blood flow quantitation
| Autor: | Chia-Lu Yeh, Huei-Fong Hung, Bor-Hsin Jong, Chi-Tai Ku, Bailing Hsu, Yen-Kung Chen, Sheng-Che Lin, Lung-Ching Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Coronary angiography
medicine.medical_specialty Myocardial ischemia Kinetic model business.industry General Medicine Blood flow medicine.disease 030218 nuclear medicine & medical imaging Coronary artery disease 03 medical and health sciences Stenosis 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cardiology Medicine Cutoff Radiology Nuclear Medicine and imaging Cutoff point business |
| Zdroj: | Annals of Nuclear Medicine. 34:682-690 |
| ISSN: | 1864-6433 0914-7187 |
| Popis: | We introduced a method to measure the extent of myocardial ischemia and steal with SPECT MBF quantitation. Eighty-seven patients who received rest/Dipyridamole-stress 99mTc-Sestamibi (MIBI) dynamic SPECT scans and coronary angiography were included. Dynamic SPECT images were reconstructed with full physical corrections. The one-tissue kinetic model was utilized to quantify K1 and further converted to MBF with required corrections. Rest MBF, stress MBF and myocardial flow reserve (MFR) were converted to a flow status polar map by a flow diagram. Extents of 7 flow statuses were verified their cutoff points for detecting stenoses. The diagnostic performance (DP) was compared to that of MFR. Cutoff point of the extent to detect ≥ 50% stenosis was 3.01% for ischemia–steal status and 20.3% for the combined status of ischemia–steal and moderate. Using these criteria, sensitivity, specificity and accuracy to detect ≥ 50% stenosis were (80%, 75%, 79%) and (86%, 68%, 80%) for ≥ 70% stenosis. The DP was superior to that of MFR |
| Databáze: | OpenAIRE |
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