Risk associated with the intake of aflatoxin M1 from milk in Iran
| Autor: | H. Yazdanpanah, Hedayat Hosseini, Michael Rychlik, A. Fooladi Moghaddam, B. Janat, M.H. Shojaee AliAbadi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aflatoxin
Metabolite 010401 analytical chemistry Public Health Environmental and Occupational Health food and beverages 04 agricultural and veterinary sciences Urine Biology Toxicology 040401 food science 01 natural sciences 0104 chemical sciences chemistry.chemical_compound 0404 agricultural biotechnology chemistry Food science Risk assessment Mycotoxin Feces Dairy cattle Food Science International agency |
| Zdroj: | World Mycotoxin Journal. 12:191-200 |
| ISSN: | 1875-0796 1875-0710 |
| DOI: | 10.3920/wmj2018.2368 |
| Popis: | Aflatoxin M1 is an oxidative metabolite of aflatoxin B1 formed in liver and excreted into milk, urine and faeces of dairy cattle and other mammalian species. The International Agency for Research on Cancer classified aflatoxin M1 in Group 2B because of its potential to get bioactivated to a mutagen analogous to aflatoxin B1. Risk assessments are undertaken to guide food regulators and scientists in risk management processes, such as the legislative levels or guideline targets for mycotoxins in food supplies. Using existing international resources for hazard data and local exposure data, and based on cancer potency as the endpoint, the risk of exposure to aflatoxin M1 in milk for the Iranian population was calculated considering various scenarios. During 2014-2015, 518 samples were collected from the market and tested for aflatoxin M1 contamination by HPLC-FLD. The most probable scenarios calculated as mean occurrence multiplied by the mean consumption in consumers of milk, and for maximum level allowed for aflatoxin M1 in milk with 99 percentiles of milk consumption showed the risk of 0.08 and 0.72 additional liver cancer cases per year for the Iranian population, respectively. Thus, our study reveals a low risk and that the current maximum limit of 100 ng/l for aflatoxin M1 in milk, heat treated milk and flavoured milk is sustainable. |
| Databáze: | OpenAIRE |
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