One pot domino reaction accessing γ-nitroesters: synthesis of GABA derivatives

Autor:	Celso Camilo Moro, Dennis Russowsky, Caroline Da Ros Montes D’Oca, Fabricio F. Naciuk, Debora Z. Vargas
Rok vydání:	2015
Předmět:	Cascade reaction Hydrotalcite Chemistry Materials Chemistry Michael reaction Nitro Organic chemistry Domino process General Chemistry Catalysis Adduct
Zdroj:	New Journal of Chemistry. 39:1643-1653
ISSN:	1369-9261 1144-0546
DOI:	10.1039/c4nj01552e
Popis:	Michael addition of 1,3-dicarbonyl compounds to nitrostyrenes is efficiently promoted by hydrotalcite [Mg–Al] to afford the respective γ-nitrodicarbonyl adducts. Differently, the addition of Meldrum's acid leads to a direct access of γ-nitroesters through a one pot domino process. GABA derivatives (+/−)-phenibut and (+/−)-baclofen were readily synthesized from the respective nitro adducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8f4992b6b43f48d5febfb5b1746dc9e https://doi.org/10.1039/c4nj01552e Zobrazit plný text záznamu