Modified picket fence porphyrin Fe(III) and Zn(II) complexes as a model for hemoglobin mutants
| Autor: | Eishin Kyuno, Hiroyasu Imai, Shigeo Nakagawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.drug_class
Inorganic chemistry chemistry.chemical_element Carboxamide Zinc Porphyrin Inorganic Chemistry Metal chemistry.chemical_compound Crystallography chemistry visual_art Materials Chemistry Via fence Structural isomer Proton NMR visual_art.visual_art_medium medicine Hemoglobin Physical and Theoretical Chemistry |
| Zdroj: | Inorganica Chimica Acta. 193:105-109 |
| ISSN: | 0020-1693 |
| DOI: | 10.1016/s0020-1693(00)83802-5 |
| Popis: | Zinc(II) and iron(III) complexes of three modified picket fence porphyrins in which one of the four pivalamido pickets was replaced by a meta-methyl, -amino, or -hydroxy benzoylamino picket were synthesized. The iron complex containing the phenolic OH on the picket fence mimics the abnormal active sites for a type of hemoglobin mutant, Hb M. Proton NMR and visible spectra for the zinc complexes have shown that the NH2 or OH group on the picket fence does not coordinate to the central metal ion in CH2Cl2 at room temperature. Contrary to this, coordination of the phenolic OH (or O−) on the picket fence to form OFeO axial geometry was found for the iron complex by ESR measurements in CH2Cl2 at 77 K. On the other hand, the ESR spectra for the three iron complexes with 1-methylimidazole under basic conditions have shown the presence of two regioisomers in OFeN axial geometry, because of the unsymmetrical distribution of the picket fences on the porphyrin plane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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