Enantioselective Pd-catalyzed allylic amination with self-assembling and non-assembling monodentate phosphine ligands

Autor:	Natalia V. Dubrovina, Christoph Waloch, Bernhard Breit, Ivan A. Shuklov, Rocco Dr. Paciello, Mandy-Nicole Birkholz, Jens Holz, Armin Börner
Rok vydání:	2007
Předmět:	Allylic rearrangement Denticity Organic Chemistry Enantioselective synthesis chemistry.chemical_element Combinatorial chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound Enantiopure drug chemistry Organic chemistry Physical and Theoretical Chemistry Phosphine Amination Palladium
Zdroj:	Tetrahedron: Asymmetry. 18:2055-2060
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2007.08.026
Popis:	New chiral phospholanes were prepared by coupling of bromo-substituted heterocycles with the enantiopure, building block (2 R ,5 R )-2,5-dimethyl-1-chlorophospholane. Some of the new phosphine ligands have the potential for self-assembling via hydrogen bondings in a metal complex. By application of these and related ligands in the palladium catalyzed allylic amination reaction, high enantioselectivities (up to 99%) were achieved. The influence of the construction of the cyclic phosphine ligands on the enantioselectivity is analyzed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8e88e43bfea048b65f0de116b3fe991 https://doi.org/10.1016/j.tetasy.2007.08.026 Zobrazit plný text záznamu Full Text from ScienceDirect