Maternal dexamethasone treatment in late gestation induces precocious fetal maturation and delivery in healthy Thoroughbred mares
| Autor: | M. Kölling, H. Kindahl, J. C. Ousey, W. R. Allen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
Fetus medicine.medical_specialty Pregnancy biology business.industry animal diseases Horse General Medicine medicine.disease Endocrinology Foal Internal medicine biology.animal medicine Gestation Endocrine system business reproductive and urinary physiology Dexamethasone Hydrocortisone medicine.drug |
| Zdroj: | Equine Veterinary Journal. 43:424-429 |
| ISSN: | 0425-1644 |
| Popis: | Summary Reasons for performing study: The foal requires an active hypothalamo-pituitary-adrenal (HPA) axis for organ maturation and post natal survival. Prenatal administration of synthetic glucocorticoids may provide an effective method for inducing fetal maturation safely in the mare. Objectives: To determine whether dexamethasone administered to late pregnant mares: 1) will induce fetal maturation and precocious delivery; 2) is safe to use and 3) to identify endocrine responses in the mare and foal. Methods: Pregnant Thoroughbred mares received either 100 mg dexamethasone i.m. (treated n = 5) or 50 ml saline i.m. (control n = 5) at 315, 316 and 317 days of gestation. Plasma progestagens, cortisol and prostaglandin F2α metabolite (PGFM) concentrations were measured before and after treatment. The foals were weighed, the crown-rump length (CRL) measured and an adrenal stimulation test performed on Day 1. Results: Dexamethasone significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text