Interactions of the Salivary and Gastrointestinal Systems

Autor:	P C Fox, Ingrid H. Valdez
Rok vydání:	1991
Předmět:	medicine.medical_specialty Saliva biology business.industry Stomach Gastroenterology General Medicine medicine.disease Cystic fibrosis medicine.anatomical_structure Internal medicine medicine biology.protein GERD Reflex Amylase Esophagus Bolus (digestion) business
Zdroj:	Digestive Diseases. 9:125-132
ISSN:	1421-9875 0257-2753
DOI:	10.1159/000171298
Popis:	Considerable evidence now demonstrates that saliva and its components have multiple functions in the GI tract. Saliva aids in bolus formation; it lubricates, protects and cleanses the pharyngeal and esophageal mucosa. Salivary bicarbonate buffers esophageal acid in common reflux. Normal salivary flow decreases the duration of acid contact with esophageal mucosa, an important factor in the development of GERD. If salivary flow is depressed or if the esophagosalivary reflex is lost, a patient may be predisposed to develop GERD. Salivary EGF stimulates GI mucosal proliferation via a direct lumenal effect in the esophagus and stomach. The salivary enzymes LL and salivary amylase initiate fat and starch digestion. They are particularly significant in patients with pancreatic insufficiency such as neonates and patients with cystic fibrosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8da7e8650062dcae71bc1c941514d32 https://doi.org/10.1159/000171298 Zobrazit plný text záznamu