Three-dimensional structure of the Arg32His mutant of the human tumor necrosis factor determined at 2.5 Å resolution from X-ray data for a twin crystal

Autor:	I. V. Artem’ev, S. V. Pletnev, Walter Pangborn, P. V. Afonin, A. V. Fokin, William L. Duax, Vladimir Z. Pletnev, I. N. Tsygannik, L. N. Shingarova, V. G. Korobko
Rok vydání:	2002
Předmět:	Necrosis Chemistry Mutant Resolution (electron density) General Chemistry Crystal structure Condensed Matter Physics Crystal Crystallography medicine General Materials Science Molecular replacement medicine.symptom Receptor Crystal twinning
Zdroj:	Crystallography Reports. 47:629-634
ISSN:	1562-689X 1063-7745
Popis:	The three-dimensional structure of the Arg32His mutant of the human tumor necrosis factor (TNF-α) was established at 2.5 A resolution by the molecular replacement method. The crystals of the mutant belong to sp. gr. R3. The specimen has a hemihedral twinning fraction of approximately one half with the twin law corresponding to an additional twofold axis along the a-or b-axis of the crystal lattice. The model analysis of interactions between functionally important loop 29–36 of the mutant and the receptors p55 and p75 was performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8d7154ea85b71434789c57cedef2bc7 https://doi.org/10.1134/1.1496062 Zobrazit plný text záznamu Plný text ve formátu PDF