Cell-specific activation of gemcitabine by endogenous H2S stimulation and tracking through simultaneous fluorescence turn-on
| Autor: | Min Hee Lee, Shin A Yoon, Sankarprasad Bhuniya, K. K. Athul, Mrinmoy Maiti, Yujin Cha |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell specific
endocrine system diseases Chemistry Metals and Alloys Endogeny Stimulation General Chemistry Prodrug equipment and supplies Fluorescence Catalysis Gemcitabine Surfaces Coatings and Films Electronic Optical and Magnetic Materials Turn (biochemistry) Cancer cell Materials Chemistry Ceramics and Composites Cancer research medicine medicine.drug |
| Zdroj: | Chemical Communications. 57:9614-9617 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | The endogenous H2S-driven theranostic H2S-Gem has been invented. The theranostic prodrug H2S-Gem is selectively activated in cancer cells, releasing active gemcitabine with a simultaneous fluorescence turn-on. H2S-Gem selectively inhibited cancer cell growth compared to the mother chemotherapeutic gemcitabine. Overall, it is a unique protocol for tracking and transporting chemotherapeutic agents to tumor areas without the guidance of tumor-directive ligands. |
| Databáze: | OpenAIRE |
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