Development and Evaluation of Kukkutandatvak bhasma tablet by using Dry Granulation Techniques
| Autor: | Priya Khalapurkar, Akshay Baheti, Manish Wani, Satish Polshettiwar, Ashwini Gawade, Amol Tagalpallewar, Varun Pande, Mrunal Sabale, Ameya Joshi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Research Journal of Pharmacy and Technology. :3764-3768 |
| ISSN: | 0974-360X 0974-3618 |
| Popis: | Aims: This study aimed to formulate and evaluate Kukkutandatvak (Hen Eggshell) bhasma tablet intended for optimum disintegration and release in the gastrointestinal tract. Methods and Material: Calcium content in Kukkutandatvak bhasma was determined using the titrimetric method. 9 formulations (F1 to F9) were prepared with Polyvinylpyrrolidone and SGS as super disintegrants. The granules were then evaluated for angle of repose, bulk density, tapped density, Hausner's ratio and Carr's index. The granules were then converted into caplet shaped tablets and were evaluated for uniformity of weight, drug content, friability, Hardness, Disintegration (in a sec) and % drug release. Results and Discussions: Calcium content in Kukkutandatvak bhasma was found to be 98%. The granules were found to be free-flowing and compressible. The Kukkutandatvak bhasma tablet had good strength and lower disintegration time (less than 135 sec), indicating a better balance between the binding and disintegration properties. The antacid activity of the tablet was evaluated by preliminary antacid test, i.e. acid-neutralizing capacity test and Rosset-Rice test. Conclusions: It was observed that Kukkutandatvak bhasma tablet (500 mg) prepared by both methods comply with Preliminary Antacid Test U.S.P. The tablet prepared neutralized 15.15 mEq of respectively in just 9.25min. |
| Databáze: | OpenAIRE |
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