Transkranielle Magnetstimulation bei Nikotinabhängigkeit
| Autor: | Rainer Wiegand, Norbert Wodarz, Alexander Kharraz, Peter Eichhammer, Gabriele Sommer, Göran Hajak, Monika Johann, Gabriela Bobbe |
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| Rok vydání: | 2003 |
| Předmět: |
Visual analogue scale
business.industry media_common.quotation_subject medicine.medical_treatment Craving Abstinence medicine.disease Transcranial magnetic stimulation Nicotine Anesthesia mental disorders behavior and behavior mechanisms medicine Dopaminergic neurotransmission medicine.symptom Nicotine dependence business psychological phenomena and processes media_common medicine.drug |
| Zdroj: | Psychiatrische Praxis. 30:129-131 |
| ISSN: | 1611-8340 1611-8332 |
| DOI: | 10.1055/s-2003-39733 |
| Popis: | 70 - 80 % of regular smokers fulfill the ICD-10-criteria of dependence. In Germany, approximately 120 000 deaths per year are caused by tobacco-associated diseases. In contrast, therapeutic interventions, such as nicotine substitution or bupropione, yield poor abstinence rates of 30 % after 12 months, at best. In animal experiments, repetitive transcranial magnetic stimulation (rTMS) exhibited modulatory effects on dopaminergic neurotransmission in regions of the so-called reward system. This pilot study should evaluate, if rTMS could modulate subjective craving for tobacco, which quite often leads to relapse to smoking. Therefore, 11 tobacco-dependent cigarette smokers were randomly assigned to a course of verum- and placebo-rTMS on consecutive days. Craving, as measured by a visual analogue scale, is significantly decreased after Verumstimulation compared to placebostimulation intra-individually. This encourages further studies to clarify, if rTMS might be helpful in achieving higher tobacco abstinence rates in smokers willing to quits. |
| Databáze: | OpenAIRE |
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