| Autor: |
Gülay Demircin, Ali Delibaş, Mehmet Bülbül, Ozlem Erdogan, Kenan Bek, Şahika Baysun, Ayse Oner |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Annals of Paediatric Rheumatology. 1:65 |
| ISSN: |
2146-2909 |
| DOI: |
10.5455/apr.110520111313 |
| Popis: |
Objective: Juvenile dermatomyositis (JDM) is a rare disease of childhood characterized by nonsuppurative inflammation of striated muscle and skin and calcinosis is one of the most important sequelae of the disease. Methods: In this study we investigated the clinical findings, complications and prognosis of 13 patients (9 girls, 4 boys) aged between 6-14 years and diagnosed to have JDM in a period of 10 years. We documented the data of the patients that had calcinosis in detail and discussed the risk factors for the development of this complication and its management. Results: Three patients (23%) developed calcinosis after 1.5-7 years during the therapy with prednisolone and one with additional methotrexate. They did not show any improvement despite aggressive therapy with anti-inflammatory drugs including prednisolone, methotrexate and colchicine together with biphophonates and diltiazem. Conclusion: Since calcinosis may develop and progress despite appropriate therapy, controlled trials including large number of patients are needed to show the optimal management of JDM to prevent the development and progression of this complication. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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