A General One-Pot Protocol for Hindered N-Alkyl Azaheterocycles from Tertiary Carboxylic Acids

Autor:	Shuilian Zhao, Takao Suzuki, Tingting Yu, Simon B. Lang, Zhiqi Qi, Jianming Bao, Rohan R Merchant
Rok vydání:	2020
Předmět:	chemistry.chemical_classification 010405 organic chemistry Chemistry Organic Chemistry Rapid access Organic chemistry Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Alkyl 0104 chemical sciences
Zdroj:	Organic Letters. 22:4180-4184
ISSN:	1523-7052 1523-7060
Popis:	In this letter, we report a general one-pot strategy that utilizes three elementary steps (decarboxylative hydrazination, Boc deprotection, and heterocycle condensation) to regioselectively prepare hindered C(sp3) substituted pyrazoles and triazoles. The operational simplicity of this sequence and ubiquity of tertiary carboxylic acids allow rapid access to hindered N-alkyl azaheterocycles that will be useful to practitioners of medicinal chemistry and agro-chemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8c7d439993e3dc5577c686cbb3db6b2 https://doi.org/10.1021/acs.orglett.0c01254 Zobrazit plný text záznamu