Effect of gliquidone on the ABCB1 protein functional activity in vivo

Autor:	D S Titov, A A Nikiforov, S. K Pravkin
Rok vydání:	2015
Předmět:	Fexofenadine biology Chemistry Substrate (chemistry) Transporter Absorption (skin) Pharmacology Pharmacokinetics In vivo biology.protein medicine Gliquidone P-glycoprotein medicine.drug
Zdroj:	I.P. Pavlov Russian Medical Biological Herald. 23:39-43
ISSN:	2500-2546 0204-3475
DOI:	10.17816/pavlovj2015439-43
Popis:	In the in vivo study in rabbits the effect of gliquidone at 10 mg / kg body weight of the functional activity of the protein transporter P-glycoprotein (P-gp, ABCB1 protein) was studied. P-gp activity was evaluated by pharmacokinetics of its marker substrate - fexofenadine after a single intragastric administration. Applying gliquidone for 14 days led to an increase in the maximum concentration of fexofenadine, its halflife, area under the concentration-time curve from zero to the last point of drawing blood, area under the concentration-time curve from zero to infinity, and the retention time of marker substrate and reduce the overall clearance and rate of absorption, indicating that the inhibition of the functional activity of the protein transporter at the level of the whole organism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8bd273b2582b8d9b9715a3423e98dce https://doi.org/10.17816/pavlovj2015439-43 Zobrazit plný text záznamu