Removal of the Olfactory Bulbs in Mice Leads to Changes in Affective Behavior

Autor:	Mu. Y. Stepanichev, O. A. Nedogreeva, Natalia V. Gulyaeva
Rok vydání:	2020
Předmět:	0301 basic medicine Elevated plus maze Affective behavior business.industry General Neuroscience 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Emotionality Medicine Anxiety medicine.symptom business Neuroscience 030217 neurology & neurosurgery
Zdroj:	Neuroscience and Behavioral Physiology. 50:892-899
ISSN:	1573-899X 0097-0549
Popis:	Removal of the olfactory bulbs induces a multitude of behavioral impairments, the most reproducible of which is hyperlocomotion. Olfactory bulbectomy is widely used to model anxiety and depression-like states. In the present study, C57Bl/6 mice subjected to olfactory bulbectomy were tested in standard tests to assess anxiety and depression-like behavior. Removal of the olfactory bulbs in mice was found to increase anxiety and emotionality. Attention in the present work was focused on the fact that hyperactivity induced by bulbectomy can seriously distort the results obtained in anxiety tests. The results lead to the conclusion that the contribution of hyperlocomotion must be taken into account in the interpretation of behavioral measures in the elevated plus maze test.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8bba67bbfde0ff2483a745a4c444122 https://doi.org/10.1007/s11055-020-00982-3 Zobrazit plný text záznamu Full text from SpringerLink