Medical History and the Risk of Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

Autor:	Kiyotaro Kondo, James A. Mortimer, V Chandra, L Fratiglioni, A B Graves, E Kokmen, C M van Duijn, A Heyman, Monique M.B. Breteler, Anthony F. Jorm
Rok vydání:	1991
Předmět:	medicine.medical_specialty Pediatrics Epidemiology business.industry Case-control study General Medicine Disease medicine.disease Confidence interval Epilepsy Relative risk medicine Dementia Medical history Alzheimer's disease Psychiatry business
Zdroj:	International Journal of Epidemiology. 20:S36-S42
ISSN:	1464-3685 0300-5771
Popis:	In a re-analysis of eight case-control studies on Alzheimer's disease we explored several medical conditions that had previously been suggested as possible risk factors for Alzheimer's disease. History of hypothyroidism was increased in cases as compared to controls (relative risk 2.3; 95% confidence interval 1.0-5.4). Severe headaches and migraine were inversely related to Alzheimer's disease (relative risk 0.7; 95% confidence interval 0.5-1.0). More cases than controls reported epilepsy before onset of Alzheimer's disease (relative risk 1.6; 95% confidence interval 0.7-3.5), especially for epilepsy with an onset within 10 years of onset of dementia. Neurotropic viruses, allergic conditions, general anaesthesia and blood transfusions were not associated with Alzheimer's disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8ba1387f74bcc2be1b9b99ecd1eb960 https://doi.org/10.1093/ije/20.supplement_2.s36 Zobrazit plný text záznamu