NURBS-based numerical proxies for red blood cells and circulating tumor cells in microscale blood flow
| Autor: | Hector Gomez, Carles Bona-Casas, Hugo Casquero |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Fåhræus–Lindqvist effect
Materials science business.industry Mechanical Engineering Dynamics (mechanics) Computational Mechanics General Physics and Astronomy 010103 numerical & computational mathematics Blood flow Isogeometric analysis Structural engineering 01 natural sciences Computer Science Applications 010101 applied mathematics medicine.anatomical_structure Circulating tumor cell Mechanics of Materials Nucleated cell medicine 0101 mathematics business Biological system Nucleus Microscale chemistry |
| Zdroj: | Computer Methods in Applied Mechanics and Engineering. 316:646-667 |
| ISSN: | 0045-7825 |
| DOI: | 10.1016/j.cma.2016.09.031 |
| Popis: | We explore the use of NURBS-based immersed fluid–structure interaction algorithms to model the dynamics and rheology of red blood cells (RBCs) and nucleated cells. Prime examples of cells with nucleus that are relevant to this study are white blood cells (WBCs) and circulating tumor cells (CTCs). In this work, RBCs are modeled as thin solid membranes called capsules. To model cells with nucleus we introduce the concept of compound capsule which explicitly takes into account the nucleus as a bulky deformable solid. Our results indicate that to reproduce the behavior of RBCs in shear and parabolic flows, it is crucial to accurately solve the mass conservation equation near the fluid–solid interface. We show results of hyperelastic capsules and compound capsules in two- and three-dimensional settings. Finally, taking advantage of the geometric flexibility of our method, we simulate how a CTC passes through a narrowing. This is a feature of CTCs that has recently triggered excitement in the experimental community. |
| Databáze: | OpenAIRE |
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