Prognosis of conventional vs. high-frequency ventilation for congenital diaphragmatic hernia: a retrospective cohort study
| Autor: | Katsuaki Toyoshima, Tadaharu Okazaki, Hiroomi Okuyama, Naoto Urushihara, Taizou Furukawa, Yuko Tazuke, Keita Terui, Keiichi Uchida, Makiko Fuyuki, Yutaka Kanamori, Satoko Ohfuji, Shoichiro Amari, Tomoaki Taguchi, Noriaki Usui, Manabu Okawada, Masaya Yamoto, Masahiro Hayakawa, Noboru Inamura, Kouji Masumoto, Akiko Yokoi |
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| Rok vydání: | 2020 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty business.industry medicine.medical_treatment High-frequency ventilation Obstetrics and Gynecology Congenital diaphragmatic hernia Retrospective cohort study Odds ratio medicine.disease Confidence interval 03 medical and health sciences 0302 clinical medicine Bronchopulmonary dysplasia 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health Propensity score matching medicine 030212 general & internal medicine business |
| Zdroj: | Journal of Perinatology. 41:814-823 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-020-00833-6 |
| Popis: | Objective To determine the appropriate initial ventilatory mode for neonatal congenital diaphragmatic hernia (CDH) by comparing patient prognosis following conventional mechanical ventilation (CMV) versus high-frequency oscillatory ventilation (HFO). Study design This multicenter retrospective cohort study was performed at 15 participating hospitals in Japan between 2011 and 2016. The 328 eligible CDH infants were classified into CMV (n = 78) and HFO groups (n = 250) to compare mortality and incidence of bronchopulmonary dysplasia (BPD). Propensity score matching was applied to reduce confounding by indication. Result While crude mortality was significantly higher in the HFO than the CMV group, adjusted odds ratio (OR) did not show significant difference in mortality between groups (OR of HFO group: 0.98, 95% confidence interval (CI): 0.57-1.67). Adjusted OR of BPD incidence showed no significant difference between groups (OR of HFO group: 1.66, 95%CI: 0.50-5.49). Conclusion Initial ventilatory mode in CDH patients, whether CMV or HFO, does not affect prognosis. |
| Databáze: | OpenAIRE |
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