Effects of Crude Aqueous Extract of Cola Acuminata Pods on the Reproductive System of Male Albino Rats
| Autor: | N. C. Azubuike, Michael C Ugwu, Ogechukwu F Odo, O. C. Ike, Chisom H Udeogu, P.U. Achukwu |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Medical Laboratory. |
| ISSN: | 2423-3714 2423-3706 |
| DOI: | 10.18502/ijml.v7i3.4139 |
| Popis: | Background and Aims: Cola acuminata pod extract (CAPE) is used in Nigerian traditional medicine to treat low sperm count in males. Hence, this study aimed to investigate the effects of CAPE on the reproductive system of male albino rats. Materials and Methods: Preliminary acute toxicity testing, phytochemical screening, proximate analysis, and determination of vitamin E concentration were performed on the extract. Three groups (I, II, and III) of 12 rats were used in the study. Each group comprised three batches (A, B, and C) of 4 rats each for different periods (4, 6, and 8 weeks, respectively). Results: Acute toxicity testing showed that CAPE had an oral lethal dose of 50% (LD50) of >5 g/kg body weight (b.wt) in rats. Vitamin E concentration was 0.511 mg/l. The caudal epididymal sperm count increased marginally from 4 to 6 weeks for rats treated with 800 mg/kg b.wt., but reduced significantly at 8 weeks for both CAPE treatment groups (II and III) (p |
| Databáze: | OpenAIRE |
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