Nitric oxide is an epigenetic regulator of histone post-translational modifications in cancer
| Autor: | Hannah Petraitis, Douglas D. Thomas, Marianne B. Palczewski |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Physiology Regulator Cancer medicine.disease Nitric oxide Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Histone Enzyme chemistry Physiology (medical) Gene expression biology.protein medicine Transcriptional regulation Epigenetics 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Physiology. 9:94-99 |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2019.05.006 |
| Popis: | Nitric oxide (nitrogen monoxide, NO) is an endogenously produced signaling molecule in cancer that regulates gene expression and cell phenotype. In recent years, new evidence has emerged regarding the roles of NO in epigenetic regulation and specifically of histone post-translational modifications (PTMs). Epigenetic effects of NO are mediated through transcriptional regulation of histone-modifying enzymes and by the ability of NO to modulate the activities and cellular localizations of these enzymes through the formation of iron–nitrosyl complexes and S-nitrosothiols. |
| Databáze: | OpenAIRE |
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