Syndecan in health and disease – A systematic review

Autor:	Silvie Singh, Smitha C N, S. K. Singh, C N Smitha, Swapna Kulkarni, Veena Bhojaraj Pujari, Manish Kumar, Himachal Pradesh, Virsen Jaysingrao Patil, Tanoj Kumar
Rok vydání:	2016
Předmět:	animal structures biology Integrin Receptor tyrosine kinase Syndecan 1 Cell biology carbohydrates (lipids) Extracellular matrix Transmembrane domain Ectodomain Biochemistry Cytoplasm embryonic structures biology.protein Cell adhesion
Zdroj:	Journal of Advanced Medical and Dental Sciences Research. 4:184-189
ISSN:	2321-9599 2348-6805
DOI:	10.21276/jamdsr.2016.4.4.38
Popis:	Syndecans are heparin sulfate protoglycans that are associated with cell surface and extra cellular matrix. Invertebrates have one syndecan core protein but in mammals there are four syndecan proteins. Each protein has three major domains; ectodomain, transmembrane domain and cytoplasmic domain. Cytoplasmic domain are the most conserved and serve to regulate the signalling of growth factors. They have also been shown to be involved in cell signalling through interaction with integrins and tyrosine kinase receptors. These cell surface proteins are thought to play an important role in cell matrix and cell - cell adhesion, migration and proliferation. So, this review summarized the structure, properties and functions of various syndecan molecules in both health and disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b8a9d8eff4350c98b3589f86023ff8cb https://doi.org/10.21276/jamdsr.2016.4.4.38 Zobrazit plný text záznamu