Pattern of adverse drug reactions in a regional pharmacovigilance center of a tertiary care teaching hospital

Autor: M.G. Rajanandh, S. Anandan, S. Adikrishnan, P. Seenivasan, P. I. Vivek
Rok vydání: 2018
Předmět:
Zdroj: Drugs & Therapy Perspectives. 34:138-141
ISSN: 1179-1977
1172-0360
DOI: 10.1007/s40267-017-0474-y
Popis: The aim of this study was to characterize the pattern of adverse drug reactions (ADRs) reported in a tertiary care teaching hospital. A retrospective study was conducted in the pharmacovigilance center of the Sri Ramachandra Medical College and Hospital, India. ADR data were evaluated for patient demographics, drug and reaction characteristics, and outcome of the reactions. Causality assessment was performed. A total of 118 ADRs were included in the analysis, with most (70%) being reported in females. Fourteen different drug categories causing ADRs were noted, with antibiotics being the most frequent. The most commonly reported ADRs were pruritus and rash, and the majority of ADRs were reported from the General Medicine Department. Upon causality assessment, the majority of ADRs were rated as being probably drug related. No statistically significant difference was found between causality assessment and age or sex. Information in the present study may be useful for identifying and minimizing preventable ADRs, and may enhance the ability of prescribers to manage ADRs more effectively and to facilitate the development of a hospital pharmacovigilance service.
Databáze: OpenAIRE
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