| Autor: |
Chintha Venkataramaiah, Jayakumar Kannali, Reddi Mohan Naidu Kalla, Chamarthi Nagaraju, Mavallur Varalakshmi, K. Pushpa Kumar, D. Venkatramana Reddy, K.Swetha Kumari |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Organic Communications. 13:155-164 |
| ISSN: |
1307-6175 |
| Popis: |
A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3-nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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