Breast-Feeding Modulates the Influence of the Peroxisome Proliferator–Activated Receptor-γ (PPARG2) Pro12Ala Polymorphism on Adiposity in Adolescents
| Autor: | Dénes Molnár, Jean Dallongeville, Esther Nova, Noemi Bevilacqua, Luis Moreno, Dominique Turck, Christina Breidenassel, Idoia Labayen, Frédéric Gottrand, Szilvia Bokor, Laurent Béghin, Enrique G. Artero, Aline Meirhaeghe, Stefaan De Henauw, Philippe Amouyel, Yannis Manios, Caroline Verier |
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| Rok vydání: | 2009 |
| Předmět: |
Advanced and Specialized Nursing
0303 health sciences medicine.medical_specialty Peroxisome proliferator-activated receptor gamma Waist business.industry Cross-sectional study Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes medicine.disease Obesity 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Genotype Internal Medicine medicine business Breast feeding Body mass index 030304 developmental biology |
| Zdroj: | Diabetes Care. 33:190-196 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE The peroxisome proliferator–activated receptor-γ2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations. RESEARCH DESIGN AND METHODS Data on breast-feeding duration, BMI, and genotypes for the Pro12Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses. RESULTS No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P < 0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e.g., Δ BMI +1.88 kg/m2, adjusted for age, sex, and center, P = 0.007) than Pro12Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Ala12 allele carriers and Pro12Pro children in terms of adiposity measurements, whatever the duration of breast-feeding. CONCLUSIONS Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents. |
| Databáze: | OpenAIRE |
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