Studies on the anti-inflammatory, analgesic and antipyrexic activities of betulinic acid derived from Tetracera Potatoria
| Autor: | Adebowale Bernard Saba, B O Oyebanji, Olayinka A. Oridupa |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Acetylsalicyclic acid biology medicine.drug_class Analgesic Zymosan Ethyl acetate Pharmacology biology.organism_classification Anti-inflammatory chemistry.chemical_compound Complementary and alternative medicine chemistry Triterpene Anesthesia Betulinic acid Drug Discovery medicine Tetracera |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines. 11 |
| ISSN: | 0189-6016 |
| DOI: | 10.4314/ajtcam.v11i1.5 |
| Popis: | Background: The anti-inflammatory and anti-nociceptive activity of betulinic acid (BA) was investigated in this study. The triterpene was isolated from the ethyl acetate extract of Tetracera potatoria and its structure was verified by IR and NMR spectroscopy. The bioactivity of this compound was assessed using carrageenan-induced paw oedema in rats and carrageenan-induced pulmonary oedema in mice for the antiinflammatory activity, while acetic acid-induced writhing test in mice and zymosan-induced fever in rats were used for analgesic test. Materials and Methods: Rats and mice were randomly divided into groups of five animals. For each experiment, betulinic acid at 10, 20 or 40mg/kg b.w was administered intraperitoneally to the first three groups respectively. The fourth group was administered with indomethacin (10mg/kg) or acetylsalicylic acid (150mg/kg), while the fifth group was administered with distilled water (10ml/kg). Data obtained were expressed as mean±S.E.M and significant differences were determined at p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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