Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement?
| Autor: | Ali Emre Oge, Bahar Erbas, Hava Özlem Dede, Emel Oguz Akarsu, Elif Kocasoy Orhan, Nermin Gorkem Sirin, Halil Atilla Idrisoglu, Mehmet Baris Baslo |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Lower motor neuron involvement Lower motor neuron 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine parasitic diseases medicine 0501 psychology and cognitive sciences Amyotrophic lateral sclerosis Lower motor neuron dysfunction FREP Stimulation technique business.industry 05 social sciences Neurophysiology medicine.disease Sensory Systems Transcranial magnetic stimulation medicine.anatomical_structure Neurology Cardiology Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology. 131:96-105 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2019.09.030 |
| Popis: | Objective To extract insight about the mechanism of repeater F-waves (Frep) by exploring their correlation with electrophysiologic markers of upper and lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). Methods The correlations of Frep parameters with clinical scores and the results of neurophysiological index (NI), MScanfit MUNE, F/M amplitude ratio (F/M%), single and paired-pulse transcranial magnetic stimulation (TMS), and triple stimulation technique (TST) studies, recorded from abductor digiti minimi (ADM) and abductor pollicis brevis (APB) muscles of 35 patients with ALS were investigated. Results Frep parameters were correlated with NI and MScanfit MUNE in ADM muscle and F/M% in both muscles. None of the Frep parameters were correlated with clinical scores or TST and TMS measures. While the CMAP amplitudes were similar in the two recording muscles, there was a more pronounced decrease of F-wave persistence in APB, probably heralding the subsequent split hand phenomenon. Conclusion Our findings suggest that the presence and density of Freps are primarily related to the degree of lower motor neuron loss and show no correlation with any of the relatively extensive set of parameters for upper motor neuron dysfunction. Significance Freps are primarily related to lower motor neuron loss in ALS. |
| Databáze: | OpenAIRE |
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