Increased histone H1 ° expression in differentiating mouse erythroleukemia cells is related to decreased cell proliferation

Autor:	Jacint Boix, Adolf Ruiz-Carrillo
Rok vydání:	1992
Předmět:	Cell cycle checkpoint Histone H1 Cell growth Cell culture hemic and lymphatic diseases Cellular differentiation Immunology Stimulation Cell Biology Cell cycle Biology Nuclear protein Cell biology
Zdroj:	Experimental Cell Research. 201:531-534
ISSN:	0014-4827
Popis:	The amount of histone H1 ° increases relative to other H1 subtypes in terminally differentiated cells, and its expression has been associated with the onset of differentiation. We have studied the kinetics of H1 ° accumulation in mouse erythroleukemia (MEL) cells and found that the levels of H1 ° reflect the rate of cell proliferation rather than the state of differentiation. This suggests that changes in the relative amount of H1 ° during MEL cell differentiation are primarily a consequence of cell cycle arrest.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b895eda4857bda4de8297d824a1269c5 https://doi.org/10.1016/0014-4827(92)90306-s Zobrazit plný text záznamu