Cross-sectional study on clinical features and histopathology of systemic sclerosis
| Autor: | Deepthi N Sureshan, Lekha Thumbayil, Najeeba Riyaz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty education.field_of_study medicine.diagnostic_test business.industry Cross-sectional study Population Histology Disease medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Fibrosis Trichrome Internal medicine Skin biopsy Medicine Histopathology business education |
| Zdroj: | Journal of Skin and Sexually Transmitted Diseases. 1:77-83 |
| ISSN: | 2582-3175 |
| DOI: | 10.25259/jsstd_29_2019 |
| Popis: | Objectives: To study the cutaneous and systemic manifestations of systemic sclerosis (SSc) and correlate the severity of cutaneous disease with extent of fibrosis on histology. Methods and Materials: Patients were evaluated for cutaneous and systemic manifestations of SSc. Cutaneous disease was assessed using modified Rodnan Skin Score (mRSS) with mRSS ≥14 indicating severe disease. Masson’s trichrome stained skin biopsy specimens were graded semi-quantitatively according to severity and extent of dermal fibrosis. Subsequently, the clinicohistological correlation was assessed. Results: Thirty-two patients were studied. Eighteen patients had diffuse cutaneous SSc while 14 had limited cutaneous SSc. Ten patients had mRSS Limitations: The prognostic significance of mRSS could not be assessed as this was a cross-sectional study. Conclusion: The cutaneous and systemic involvement observed in this study was comparable to the findings in other studies. The changes observed in frequency of specific manifestations in different population groups point to the role of genetic and environmental factors in the disease process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|