Interactome Analysis of 11-Dehydrosinulariolide-Treated Oral Carcinoma Cell Lines Such as Ca9-22 and CAL-27 and Melanoma Cell Line
| Autor: | Mona Azodi-Zamanian, Mostafa Rezaei-Tavirani, Ali Asghar Peyvandi, Shahrokh Khoshsirat, Akram Safaei |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Cancer Translation (biology) Computational biology Biology medicine.disease Proteomics Interactome Protein–protein interaction 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Drug development Cell culture 030220 oncology & carcinogenesis Cancer cell medicine Pharmacology (medical) Radiology Nuclear Medicine and imaging Surgery |
| Zdroj: | International Journal of Cancer Management. 10 |
| ISSN: | 2538-497X 2538-4422 |
| DOI: | 10.5812/ijcm.10096 |
| Popis: | Background: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies in head and neck. The patients usually have a poor prognosis because they do not understand the significance of early symptoms. Then, the timely treatment may be lost. In recent years, network analysis is growing in the target identification concepts and can provide opportunities in pathway analysis. These could provide valuable information for drug development and progression monitoring of cancers such as OSCC. Methods: PubMed Database was used as the main source and “Oral cancer” and “11-dehydrosinulariolide” and “Proteomics” were the keywords for the search process. We focused on articles that studied the differentially expressed proteins of cell lines of OSCC (Ca9-22 and CAL-27) and melanoma cell line (A2058) after 11-dehydrosinulariolideon treatment. The topological features of differentially expressed proteins were analyzed using Cytoscape Version 3.4.0. Module selection of the protein-protein interactions (PPI) networks was done using MCODE plug-in. In addition, gene ontology (GO) enrichment analysis of modules in related PPI networks was assessed. Results: Network analysis show that UBC, HSPA5 and GAPDH are the common central proteins between the three treated cell lines. The GO terms of the gene list of each of the correlated modules of networks are mostly related to four functions such as protein folding and assembly, metabolic processes, translation, and apoptotic pathways. Conclusions: Despite introduction of different protein panels related to the effect of 11-dehydrosinulariolide on cancerous cell lines in the previous studies, here a common biomarker panel is represented. |
| Databáze: | OpenAIRE |
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