Highly selective and efficient synthesis of 3-arylamino-substituted 5-aminopyrazole-4-carboxylates under microwave irradiation
| Autor: | Felicia Phei Lin Lim, Rowena Xin Yi Gan, Anton V. Dolzhenko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Organic Chemistry Hydrazine 010402 general chemistry Highly selective 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Microwave irradiation Organic chemistry Selectivity Microwave |
| Zdroj: | Tetrahedron Letters. 58:775-778 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.01.028 |
| Popis: | An improved microwave-assisted method was developed for the preparation of ethyl 5-aminopyrazole carboxylates from ethyl 2-cyano-3-methylthioacrylates and hydrazine. It was shown that using microwave irradiation significantly reduced the reaction time and improved the process selectivity and yield. The reaction proved to be reproducible in different microwave reactors and on large scale, affording the desired products in high yields and purity. A representative library of 3-arylamino-substituted 5-aminopyrazole-4-carboxylates was successfully prepared to assess the scope of the method. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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