ChemInform Abstract: Total Synthesis of Fluoxetine and Duloxetine Through an in situ Imine Formation/Borylation/Transimination and Reduction Approach

Autor:	Elena Fernández, Adam D. J. Calow, Andrew Whiting
Rok vydání:	2014
Předmět:	In situ Fluoxetine Imine Total synthesis General Medicine Borylation Medicinal chemistry Catalysis Reduction (complexity) chemistry.chemical_compound chemistry medicine Duloxetine medicine.drug
Zdroj:	ChemInform. 46
ISSN:	0931-7597
DOI:	10.1002/chin.201503216
Popis:	An efficient, catalytic, asymmetric route to both (R)-fluoxetine (II) and (S)-duloxetine (IV) through the asymmetric copper-mediated β-borylation of α,β-unsaturated imines is developed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b86e258738c9edaf5dad0f6678d4c63c https://doi.org/10.1002/chin.201503216 Zobrazit plný text záznamu Plný text