Neuronal synchronization enhanced by neuron–astrocyte interaction
| Autor: | Evgeniya V. Pankratova, Sergey V. Stasenko, Ivan Lazarevich, Susanna Yu. Gordleeva, Alena I. Kalyakulina, V. B. Kazantsev |
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| Rok vydání: | 2019 |
| Předmět: |
Chemistry
Applied Mathematics Mechanical Engineering Aerospace Engineering Ocean Engineering 01 natural sciences medicine.anatomical_structure nervous system Control and Systems Engineering Postsynaptic potential Neuronal synchronization 0103 physical sciences Tripartite synapse Excitatory postsynaptic potential medicine Premovement neuronal activity Synaptic current Neuron Electrical and Electronic Engineering 010301 acoustics Neuroscience Astrocyte |
| Zdroj: | Nonlinear Dynamics. 97:647-662 |
| ISSN: | 1573-269X 0924-090X |
| DOI: | 10.1007/s11071-019-05004-7 |
| Popis: | In this study, we consider the problem of signal processing in neuron–astrocyte networks where the intercellular communication is described on the basis of a tripartite synapse concept. This type of communication involves combined contributions of pre- and postsynaptic neuronal compartments and components of the surrounding astrocyte to the processes of information transmission. Astrocyte-mediated regulation of neuronal activity is considered through the analysis of the response changes in the classical Hodgkin–Huxley model driven by excitatory synaptic current. It is shown that the complicated astrocyte-dependent dynamics of this current can lead to non-trivial changes in individual postsynaptic neuronal activity and, hence, in the cooperative activation of neuronal groups linked by the “astrocyte-mediated bridge”. |
| Databáze: | OpenAIRE |
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