Effect of tick saliva on immune interactions between Borrelia afzelii and murine dendritic cells
| Autor: | Jana Páleníková, M. Slámová, A. Skallová, Jan Kopecký |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Saliva
Ixodes ricinus Phagocytosis Immunology chemical and pharmacologic phenomena hemic and immune systems Dendritic cell Biology Tick bacterial infections and mycoses Borrelia afzelii medicine.disease_cause biology.organism_classification Microbiology Immune system Borrelia parasitic diseases medicine Parasitology |
| Zdroj: | Parasite Immunology. 33:654-660 |
| ISSN: | 0141-9838 |
| DOI: | 10.1111/j.1365-3024.2011.01332.x |
| Popis: | SUMMARY Interaction between mouse dendritic cells (DCs) and Borrelia afzelii spirochetes was monitored on three different levels: phagocytosis of spirochetes by DCs, production of cytokines by Borrelia-stimulated DCs and the ability of Borrelia-exposed DCs to activate specific CD4+ T lymphocytes. The effect of Ixodes ricinus tick saliva on each of these interactions was examined. Tick saliva was shown to decrease the number of phagocytosing DCs. The ability of Borrelia-exposed DCs to induce both proliferation and IL-2 production by specific CD4+ T cells was significantly reduced by tick saliva. And surprisingly, we have shown an inhibitory effect of tick saliva on the production of both Th1 (TNF-a and IL-6) and Th2 (IL-10) cytokines by DCs. Our data reveal a complex inhibitory effect of tick saliva on Borrelia–DCs interaction. |
| Databáze: | OpenAIRE |
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