| Popis: |
One of the major obstacles limiting the effectiveness of chemotherapeutic programmes is the inability of the present drug inventory to discriminate normal from malignant neoplastic tissue. As the search for selective anticancer drugs has been largely ineffective to date, considerable research effort has been directed toward the development of drug carrier systems1. One of the systems being investigated are closed vesicles composed primarily of phospholipids2,3. Liposomes have been extensively used as models3,4 for biological membrane research and have contributed to understanding the physico-chemical properties of biological membranes6,7. They have also advanced our understanding of cell-cell recognition8,9, fusion10,11 and protein-lipid interaction12,13. The self-assembly properties of phospholipid amphiphiles make possible the entrapment of water soluble compounds within the aqueous lumen of the liposome14. It became evident that entrapment of enzymes within liposomes might provide a therapeutic vehicle useful in treatment of diseases of enzyme deficiency15,16. |
