| Autor: | Cristina M. Junta, Geneviève Victorero, Renato S. Cardoso, Claudia Macedo, Aline R. Espanhol, Geraldo Aleixo Silva Passos, Bertrand Jordan, Béatrice Loriod, Catherine Nguyen |
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| Rok vydání: | 2003 |
| Předmět: |
Genetics
0303 health sciences Strain (biology) medicine.medical_treatment Clinical Biochemistry V(D)J recombination Cell Biology General Medicine Biology Molecular biology Gene expression profiling 03 medical and health sciences 0302 clinical medicine Cytokine Recombinase medicine Superantigen Receptor Molecular Biology Gene 030304 developmental biology 030215 immunology |
| Zdroj: | Molecular and Cellular Biochemistry. 252:223-228 |
| ISSN: | 0300-8177 |
| DOI: | 10.1023/a:1025556510001 |
| Popis: | The V(D)J recombination of TCRα and β in early developing T-cells is a highly modulated phenomenon initiated and completed by recombinase complex (RAG-1 and RAG-2), and regulated by other gene products such as interleukins. To further evaluate the association of several other gene products with the evolution of TCRVβ8.1 V(D)J rearrangements in vivo, the mRNA expression levels of seven interleukins, three cytokines, receptors TCRVβ8.1 and IL-2Rβ, MHC-I/MHC-II, RAG-1/RAG-2 and retroviral superantigen MMTV(SW) were measured by RT-PCR during the fetal development of the thymus of three inbred mouse strains (Balb-c, C57Bl/6 and CBA/J). Clustering using the Tree View software, was used to organize these genes based on similarity of expression patterns. Each strain displayed a different expression profile during thymus ontogeny. |
| Databáze: | OpenAIRE |
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