Influence de la Nature de l'Hétéroatome d'un Dérivé Monosaccharidique sur son Action Inhibitrice vis à vis de Canaux Calciques Apparentés au Type P Exprimés dans l'Ovocyte de Xenopus
| Autor: | Lahyani A, Gérard Brûlé, Fabrice Matifat, M Idaomar, Villa P, Ronco G, T. Collin, Denis Postel |
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| Rok vydání: | 1996 |
| Předmět: |
Sodium channel activity
chemistry.chemical_classification Voltage-dependent calcium channel biology Physiology Stereochemistry Xenopus chemistry.chemical_element Biological activity Ether General Medicine Calcium biology.organism_classification chemistry.chemical_compound Thioether chemistry Aldose Physiology (medical) |
| Zdroj: | Archives of Physiology and Biochemistry. 104:43-49 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1076/apab.104.1.43.12871 |
| Popis: | Our results demonstrate that saccharidic derivatives obtained by adding a C8 alkyl group through various heteroatomes (O, N or S) to a monoacetonide residue possess an inhibitory effect towards putative P-type calcium channels expressed in Xenopus oocytes. These derivatives partially and reversibly inhibit the activity of these channels without changing their electrophysiological properties. Nevertheless, the derivative containing the heteroatome N also affects the fast and tetrodotoxin-sensitive sodium channel activity. Thus, only ether and thioether compounds (heteroatome O or S) can be selected for their inhibitory effect on P-type apparented calcium channels. |
| Databáze: | OpenAIRE |
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