| Autor: |
H. U. Nwanjo, H. A. Waribo, N. Nduka, E. S. Bartimaeus |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
International Journal of Biochemistry Research & Review. :1-15 |
| ISSN: |
2231-086X |
| DOI: |
10.9734/ijbcrr/2019/v27i430127 |
| Popis: |
Acetaminophen, used for antipyretic and analgesic purposes has been known to exhibit toxic effects on the organs because of its ability to generate free radicals, causing varieties of diseases. This study investigated the impact of the combined formed of Garcinia kola seed and Vitamin E pretreatment exposure on hepatotoxicity and oxidative stress induced by acetaminophen in Albino Rats. Five groups of animals were used for this study. Group 1 as the control received distilled water orally only, group 2 as toxicity control intoxicated with 800 mg acetaminophen intraperitoneally. The other three groups were pretreated with various doses of either Garcinia kola seed extract or vitamin E or a combined form respectively by oral gavage method for 7 days before induction with acetaminophen intraperitoneally on the 8th day and sacrificed under chloroform anaethesia. Acetaminophen induction significantly rise (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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