| Popis: |
The micronutrient iron is a risk factor for type II diabetes (T2D) . The effects of iron are, in part, mediated by the iron-sensing hypoxia inducible factor (HIF) pathway. The interactions of iron and hypoxia in the progression of T2D are not fully understood. Mice were fed a fast-food (FF) diet supplemented with either normal iron (35 mg/kg) or high iron (2000 mg/kg) under normoxia and hypoxia. Hypoxic mice had a significant reduction in weight compared to normoxic mice (by 16% for 35mg-Fe diet and 14% for 2000mg-Fe diet, p Disclosure A. V. Harrison: None. D. A. Mcclain: None. S. T. Sink: None. F. Lorenzo: None. Funding NIDDK Research Service of the Veterans Administration |
