Inclusion complex between cisplatin and single-walled carbon nanotube: An integrated experimental and theoretical approach
| Autor: | Rodrigo L. Lavall, Leonardo A. De Souza, Camila A.S. Nogueira, Paulo F.R. Ortega, Juliana Fedoce Lopes, Wagner B. De Almeida, Hállen D.R. Calado, Hélio F. Dos Santos, Glaura G. Silva |
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| Rok vydání: | 2016 |
| Předmět: |
Chemistry
chemistry.chemical_element Nanotechnology 02 engineering and technology Carbon nanotube 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Molecular physics 0104 chemical sciences law.invention Characterization (materials science) Inorganic Chemistry symbols.namesake law Drug delivery Materials Chemistry symbols Molecule Wavenumber Physical and Theoretical Chemistry Inclusion (mineral) 0210 nano-technology Raman spectroscopy Carbon |
| Zdroj: | Inorganica Chimica Acta. 447:38-44 |
| ISSN: | 0020-1693 |
| Popis: | This paper describes an integrated experimental and theoretical analysis for the synthesis and characterization of cisplatin/single-walled carbon nanotube inclusion complex (cDDP@SWCNT). Experimental data revealed the inclusion of cDDP into a short SWCNT, which was predicted to be energetically favorable by around −5.0 kcal mol −1 through quantum chemical calculations. The Raman spectra show that the ratio of intensity for G/D bands decreases from 10.9 (pristine SWCNT) to 4.8 (inclusion complex), suggesting an increase of structural disorder after the drug inclusion. Moreover, it was observed a decrease of the wavenumber in the spectral range of the radial breathing modes (RBM) by ∼9 cm −1 with the insertion of the cDDP molecules. As a continuation of the studies conducted by our group, through this theoretical and experimental work we expect to help experimentalists in the assignments of Raman spectra and contribute for characterization of such carbon-based drug delivery systems. |
| Databáze: | OpenAIRE |
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