| Autor: | S F Biketov, Ostrovskiĭ Dn, Bakhteeva, V D Potapov, Demina Gr, G M Titareva, Lysak Ei |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Mutant
biochemical phenomena metabolism and nutrition Biology medicine.disease biology.organism_classification Applied Microbiology and Biotechnology Biochemistry 2-C-Methyl-D-erythritol-2 4-cyclopyrophosphate Microbiology Tularemia chemistry.chemical_compound Immune system chemistry medicine Stress conditions Bacteria |
| Zdroj: | Applied Biochemistry and Microbiology. 37:238-242 |
| ISSN: | 0003-6838 |
| Popis: | A strong immunomodulatory effect of 2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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