ChemInform Abstract: Metathetic Sulfur Transfer Mediated by N-(2-Aminophenyl)-4-methyl-thiazolin-2-thione Derivatives: A Route to Diversely Substituted S-Alkylcarbamothioates

Autor:	Mohammed Amine Mehdid, Federico Andreoli, Nicolas Vanthuyne, Abdallah Larbi Doukara, Christian Roussel, Ayada Djafri
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Benzimidazole Base (chemistry) chemistry.chemical_element General Medicine Alkylation Nitrogen Medicinal chemistry Sulfur chemistry.chemical_compound chemistry Urea Organic chemistry After treatment
Zdroj:	ChemInform. 41
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.201027081
Popis:	A new route to S-alkylcarbamothioates is disclosed. In a first step, N-(2-aminophenyl)-4-methyl-thiazolin-2-thione is transformed into a mono- or disubstituted urea at nitrogen, and then in a second step, alkylated at sulfur. The resulting salts, after treatment with a base, gave S-alkylcarbamothioates in high isolated yields together with 3-methyl[1,3]thiazolo[3,2-a]benzimidazole under very mild conditions.
Databáze:	OpenAIRE
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