| Autor: |
M. Sasahira, A. Haruzono, Wataru Hirakawa, T. Asakura, T. Fujimoto, K. Nakamura |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Proceedings of the XV Symposium Neuroradiologicum ISBN: 9783642794360 |
| DOI: |
10.1007/978-3-642-79434-6_123 |
| Popis: |
The subjects of this study were 36 epilepsy patients aged 8–62 years, who were examined 45 times; 25 had partial and 11, generalised seizures.31-chemical shift imaging (CSI) was acquired with three-dimensional Fourier transformation (3DFT) multivoxel spectroscopy. The 31P-CSI method detected abnormalities in 30 of the 36 patients (83.3%), 25 of whom had partial seizures. In patients with no apparent organic lesion, an elevation in organic phosphate (Pi) levels was observed in the peri-ictal stage. Twenty-two patients also underwent 123I-IMP and 99mHM-PAO single photon emission CT (SPECT), and 19 of them were found to have hypoperfusion in the regions identical to those appearing abnormal on CSI. One patient in whom no abnormalities had previously been observed was found to have abnormalities on CSI. In patients with apparent organic lesions, the signals of phosphocreatine (PCr), ATP and Pi were lower in the pathological hemisphere than in the contralateral hemisphere. These changes in phosphate levels seem to suggest that energy metabolism was reduced in the brain regions around the seizure foci in the interictal stage. Imaging diagnosis plays an important role in identifying seizure foci. 31P-CSI appeared to be effective for diagnosing the disease foci in patients with refractory epilepsy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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