Transient Interruption of Arterial Thrombosis by Inhibition of Factor Xa Results in Long-term Antithrombotic Effects in Baboons
| Autor: | V. Van Wyk, S Lamprecht, Philip N. Badenhorst, Harry F. Kotze, J. P. Roodt |
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| Rok vydání: | 1997 |
| Předmět: | |
| Zdroj: | Thrombosis and Haemostasis. 77:1137-1142 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1656126 |
| Popis: | SummaryRecombinant tick anticoagulant peptide (r-TAP) is a potent and specific inhibitor of activated coagulation factor X which effectively interrupts in vivo arterial thrombosis during treatment. It is, however, uncertain if it also affects thrombosis after treatment is stopped. This was tested in a baboon model of arterial thrombosis where platelet deposition onto Dacron vascular graft segments, inserted as extensions into permanent femoral arteriovenous shunts, was measured. The baboons were intravenously treated with 10 μg/kg/min (low dose, aPTT = 39 ± 1 s) and 25 μg/kg/min (high dose, aPTT = 58 ± 2 s) r-TAP for two hours. During treatment the r-TAP inhibited thrombin formation and dose-dependently interrupted platelet deposition onto the graft segment. This effect lasted for up to two hours after treatment with the low dose. Following treatment with the high dose, the graft segments were kept in place for 53 h. After treatment was stopped, platelets again deposited, but at a much lower rate than in control studies. Maximum deposition was approximately 38% lower than in the control studies. Total platelet deposition over 55 h, calculated as the area under the deposition curve, was approximately 40% (p |
| Databáze: | OpenAIRE |
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